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Therapeutics and Clinical Risk Management
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Current and emerging treatments for the management of myasthenia gravis
Review
(2120) Views (936) Full article downloads
Authors: Sathasivam S
Published Date July 2011
Volume 2011:7 Pages 313 - 323
DOI: http://dx.doi.org/10.2147/TCRM.S14015
Sivakumar SathasivamThe Walton Centre NHS Foundation Trust, Lower Lane, Liverpool, UK
Abstract: Myasthenia gravis is an autoimmune neuromuscular disorder. There are several treatment options, including symptomatic treatment (acetylcholinesterase inhibitors), short-term immunosuppression (corticosteroids), long-term immunosuppression (azathioprine, cyclosporine, cyclophosphamide, methotrexate, mycophenolate mofetil, rituximab, tacrolimus), rapid acting short-term immunomodulation (intravenous immunoglobulin, plasma exchange), and long-term immunomodulation (thymectomy). This review explores in detail these different treatment options. Potential future treatments are also discussed.
Keywords: acetylcholinesterase inhibition, immunosuppression, immunomodulation, thymectomy
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