skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8847

Correlation of central corneal thickness and axial length to the optic disc and peripapillary atrophy among healthy individuals, glaucoma and ocular hypertension patients

Original Research

(2910) Views  (758) Full article downloads

Authors: George Tomais, Gerasimos Georgopoulos, Chryssanthi Koutsandrea, Michalis Moschos

Published Date October 2008 Volume 2008:2(4) Pages 981 - 988
DOI: http://dx.doi.org/10.2147/OPTH.S4293

George Tomais1, Gerasimos Georgopoulos2, Chryssanthi Koutsandrea2, Michalis Moschos2

1University of Athens, Department of Ophthalmology, Athens, Greece; 2Athens University Medical School, Department of Ophthalmology, Athens, Greece

Purpose: Clinical observational study for the correlation between the central corneal thickness (CCT), axial length (AXL), optic disc area (D), cupping area (C) and peripapillary atrophy (PPA), in healthy eyes (group A), eyes with primary open angle glaucoma (POAG) (group B) and eyes with ocular hypertension (OH) (group C), in order to assess the possible contribution of this correlation to the diagnosis or prognosis of glaucoma.

Methods: Ninety eyes of 90 persons participated in the study (30 eyes of 30 persons in each group). All eyes underwent intraocular pressure measurement, visual field testing, endothelial cell count (ECC), measurement of the CCT and AXL, and gonioscopy. After dilation of the pupil, a digital photograph of each optic disc was performed, followed by PPA, D area and C area measurements.

Results: We found a statistically significant difference in the C/D area ratio between healthy and POAG eyes and a moderate negative relationship between AXL and D in healthy eyes. We also found a moderate negative relationship between CCT and C/D area ratio in POAG eyes and a strong negative relationship between PPA and D in OH eyes.

Conclusions: CCT was not correlated with PPA and AXL in any one of the three groups. OH eyes seem to have more tolerant and stable disc and peripapillary area compared to healthy and POAG eyes.

Keywords: glaucoma, peripapillary, cupping, corneal thickness, axial length, optic disc








Readers of this article also read:

Evaluation of adherence to morning versus evening glaucoma medication dosing regimens
Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent
Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy
Age and disease-related structural changes in the retinal pigment epithelium
Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
Unilateral retinitis pigmentosa and cone-rod dystrophy
Efficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension
Corneal abrasion
Efficacy and tolerability of the fixed combination of brinzolamide 1% and timolol 0.5% in daily practice