skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8847

Computational methods for the identification of microRNA targets

Review

(3007) Views  (1642) Full article downloads

Authors: Yang Dai, Xiaofeng Zhou

Published Date May 2010 Volume 2010:2 Pages 29 - 39
DOI: http://dx.doi.org/10.2147/OAB.S6902

Yang Dai1, Xiaofeng Zhou2

1Department of Bioengineering, Department of Computer Science, College of Engineering, 2Center for Molecular Biology of Oral Diseases, College of Dentistry, and Graduate College, UIC Cancer Center, University of Illinois at Chicago, Chicago, IL, USA

Abstract: MicroRNAs are pivotal regulators of development and cellular homeostasis. They act as post-transcriptional regulators, which control the stability and translation efficiency of their target mRNAs. The prediction of microRNA targets and detection of microRNA-mRNA regulatory modules (MRMs) are crucial components for understanding of microRNA functions. Numerous computational methods for microRNA target prediction have been developed. Computationally-predicted targets have been recently used in the integrative analysis of microRNA and mRNA expression analysis to identify microRNA targets and MRMs. In this article we review these recent developments in the integrative analysis methods. We also discuss the remaining challenges and our insights on future directions.

Keywords: microRNA target prediction, integrative analysis, microRNA regulatory mechanism, microRNA profiling, mRNA expression profiles








Readers of this article also read:

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Refinement of rigid-body protein–protein docking using backbone and side-chain minimization with a coarse-grained model
Modeling short-term antidepressant responsiveness with artificial neural networks
The interpretation of protein structures based on graph theory and contact map
Treatment of Parkinson's disease: nanostructured sol–gel silica–dopamine reservoirs for controlled drug release in the central nervous system
Biosimilars: an overview
Interpreting clinical assays for histone deacetylase inhibitors
Changes in corneal parameters at confocal microscopy in treated glaucoma patients
A novel high-throughput analysis approach: immune response-related genes are upregulated in age-related hearing loss
Inherited and acquired alterations in development of breast cancer