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Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells

Review

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Authors: Satya Prakash, Aleksandra Malgorzata Urbanska

Published Date September 2008 Volume 2008:2(3) Pages 355 - 378
DOI: http://dx.doi.org/10.2147/BTT.S2372

Satya Prakash, Aleksandra Malgorzata Urbanska

Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

Abstract: There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases like colorectal cancer, inflammatory bowel disease, and other GI tract diseases like intestinal obstruction and gastritis, but also to deliver therapeutic molecules for overall therapy in various diseases such as renal failure, coronary heart disease, hypertension, and others. This review provides a comprehensive summary of recent advancement in colon targeted live bacterial cell biotherapeutics. Current status of bacterial cell therapy, principles of artificial cells and its potentials in oral delivery of live bacterial cell biotherapeutics for clinical applications as well as biotherapeutic future perspectives are also discussed in our review.

Keywords: biotherapeutics, probiotic, microcapsules, gastrointestinal tract, colon, oral delivery, immobilization, artificial cells, bacterial cells






 

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Erratum
Mitotic and antiapoptotic effects of nanoparticles coencapsulating human VEGF and human angiopoietin-1 on vascular endothelial cells
A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis
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