skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8847

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

(3166) Views  (897) Full article downloads

Authors: Trung D Tran, Shelton D Caruthers, Michael Hughes, John N Marsh, Tillmann Cyrus, et al

Published Date January 2007 Volume 2007:2(4) Pages 515 - 526
DOI: http://dx.doi.org/10.2147/IJN.S

Trung D Tran1, Shelton D Caruthers1,2, Michael Hughes1, John N Marsh1, Tillmann Cyrus1, Patrick M Winter1, Anne M Neubauer1, Samuel A Wickline1, Gregory M Lanza1

1Division of Cardiology, Washington University Medical School, 660 South Euclid Blvd, St Louis, Missouri, USA; 2Philips Medical Systems, Cleveland, Ohio, USA

Abstract: Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.

Keywords: nanoparticles, perfluorocarbon, molecular imaging, ultrasound, magnetic resonance imaging








Readers of this article also read:

Nano-liposomal dry powder inhaler of tacrolimus: Preparation, characterization, and pulmonary pharmacokinetics
Applications of gold nanoparticles in cancer nanotechnology
Evidence-based decision-making within the context of globalization: A “Why–What–How” for leaders and managers of health care organizations
Periosteoplasty for covering gingival recessions: Clinical results
Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
"Globalized public health.” A transdisciplinary comprehensive framework for analyzing contemporary globalization’s influences on the field of public health
Amino acid-responsive Crohn's disease: a case study
Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube
A new era of cancer treatment: carbon nanotubes as drug delivery tools
A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis