skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8847

Changes in visual function and thickness of macula after photodynamic therapy for age-related macular degeneration

Original Research

(2062) Views  (664) Full article downloads

Authors: Kyoko Okada, Mariko Kubota-Taniai, Masayasu Kitahashi, et al

Published Date September 2009 Volume 2009:3 Pages 483 - 488
DOI: http://dx.doi.org/10.2147/OPTH.S6584

Kyoko Okada, Mariko Kubota-Taniai, Masayasu Kitahashi, Takayuki Baba, Yoshinori Mitamura, Shuichi Yamamoto

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan

Purpose: To determine the correlation between the changes in the central retinal sensitivity and the changes in the foveal thickness (FT) after photodynamic therapy (PDT) for age-related macular degeneration (AMD).

Methods: Nineteen eyes of 19 patients with choroidal neovasularizations (CNVs) secondary to AMD were studied. The pretreatment values of the central retinal sensitivity determined by Micro Perimeter 1 (MP1; Nidek Technologies), best-corrected visual acuity (BCVA), and optical coherence tomography (OCT)-determined FT were compared to the postoperative values at three and six months after PDT.

Results: At six months, the retinal sensitivity within the central 10° was significantly improved (P = 0.02) and the FT was significantly thinner (P = 0.016). The BCVA, however, did not change significantly (P = 0.80). The changes in the retinal sensitivities were significantly correlated with the changes in the decrease in the FT (r = -0.59, P = 0.012 within the central 10°) at six months after PDT.

Conclusion: Significant improvements in retinal sensitivities within the central 10° and a decrease in FT were observed even though the BCVA was not significantly improved. The measurement of retinal sensitivity by MP1 may be a better method to assess central visual function than the conventional visual acuity after PDT.

Keywords: age-related macular degeneration, fundus-related microperimetry, optical coherence tomography, photodynamic therapy








Readers of this article also read:

Treatment of neovascular age-related macular degeneration: Current therapies
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures
Bevacizumab (Avastin®) for the management of anterior chamber neovascularization and neovascular glaucoma
Toxoplasma retinochoroiditis in pregnancy: Using current evidence to inform management
Perception of risk and benefit in patient-centered communication and care
The relationship between deliberate self-harm behavior, body dissatisfaction, and suicide in adolescents: current concepts
Zinc oxide nanoparticles as selective killers of proliferating cells
Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy