Open Access Animal Physiology
Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss
(6229) Total Article Views
Authors: Robert D Frisina, Xiaoxia Zhu
Published Date June 2010
Volume 2010:2 Pages 9 - 16
Robert D Frisina, Xiaoxia Zhu
Otolaryngology, Biomedical Engineering, Neurobiology, and Anatomy Departments, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Abstract: Age-related hearing loss is a highly prevalent sensory disorder, from both the clinical and animal model perspectives. Understanding of the neurophysiologic, structural, and molecular biologic bases of age-related hearing loss will facilitate development of biomedical therapeutic interventions to prevent, slow, or reverse its progression. Thus, increased understanding of relationships between aging of the cochlear (auditory portion of the inner ear) hair cell system and decline in overall hearing ability is necessary. The goal of the present investigation was to test the hypothesis that there would be correlations between physiologic measures of outer hair cell function (otoacoustic emission levels) and hearing sensitivity (auditory brainstem response thresholds), starting in middle age. For the CBA mouse, a useful animal model of age-related hearing loss, it was found that correlations between these two hearing measures occurred only for high sound frequencies in middle age. However, in old age, a correlation was observed across the entire mouse range of hearing. These findings have implications for improved early detection of progression of age-related hearing loss in middle-aged mammals, including mice and humans, and distinguishing peripheral etiologies from central auditory system decline.
Keywords: presbycusis, hearing loss, hair cells, auditory brainstem response, otoacoustic emissions, mouse hearing
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Other articles by Professor Robert Frisina
Readers of this article also read:
Call For Submissions
Submit Original Research Article, Review, Case Report, or Rapid Communication in Open Access Animal Physiology
- Evolution of a domain conserved in microtubule-associated proteins of eukaryotes
- Is gene activity in plant cells affected by UMTS-irradiation? A whole genome approach
- Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease
- Discrimination between biological interfaces and crystal-packing contacts