International Journal of General Medicine
Open access peer-reviewed scientific and medical journals.
Dove Medical Press is now a member of the Open Access Initiative
An Author's Guide
A guide to help authors get their paper published.
Support Open Access and Dove Press
Promotional Article Monitoring - further details
Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Effects of selective serotonin reuptake inhibitors on motor neuron survival
(32755) Total Article Views
Authors: Lily B Anderson, Phaedra B Anderson, Thea B Anderson, Amy Bishop, et al.
Published Date May 2009
Volume 2009:2 Pages 109 - 115
Lily B Anderson1, Phaedra B Anderson1, Thea B Anderson1, Amy Bishop2, James Anderson2
1Cherokee Labsystems, Huntsville, AL USA; 2Department of Biology, University of Alabama in Huntsville, Huntsville, AL, USA
Abstract: Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and paroxetine are prescribed to relieve clinical depression and a variety of other disorders. Recently tardive dyskinesia, as well as other movement disorders, have been found to be a clinical side effect of SSRIs. In light of these emerging side effects, we asked if motor neurons were affected by SSRI. Motor neurons were challenged with fluoxetine and paroxetine at clinically relevant doses as well as at lesser and greater doses. Ethanol was used as a negative control and another group of cells was left untreated. As expected, in alcohol-treated cells, there was significant decrease in cell survival and neurite outgrowth. In untreated cells there was no effect in either cell survival or neurite outgrowth. In fluoxetine-treated motor neurons there was ~52% cell death while in paroxetine-treated cells there was 14% cell survival and both SSRIs caused significant loss of the percentage of neurite-bearing cells. Both SSRIs decreased cell survival in a dose-dependent manner. This study is provocative enough to call for further in vivo studies.
Keywords: fluoxetine, paroxetine, motor neurons, NSC34, neurotoxicity, SSRI
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
"I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University.
- Effects of selective serotonin reuptake inhibitors on motor neuron survival
- Amino acid management of Parkinson’s disease: a case study
- Review of evidence for immune evasion and persistent infection in Lyme disease
- Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia