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Noteworthy comment: This article is noteworthy, in that it helps us understand the potential problems associated with transdermal delivery systems - not only of opioids, but of a wider range of medications. Our hope is that this study will result in increased appreciation of individual differences in pain medication response.

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Poor adhesion of fentanyl transdermal patches may mimic end-of-dosage failure after 48 hours and prompt early patch replacement in hospitalized cancer pain patients

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