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Noteworthy comment: This paper reviews publically-available gene expression array data and characterizes luminal B cancer as a unique subtype of breast cancer that has a distinct biology from luminal A cancer. Breast cancer is a highly heterogeneous disease and the difficulty with its molecular classification using methods such as hierarchical clustering is making the distinction between subsets within the major classes. Inevitably there is overlap in genotypes and so practically, clinical utility is achieved by categorisation of patients into good and poor prognosis. It remains an ideal to be able to do this for all breast cancer patients at different stages of their disease using techniques compatible with current procedures.

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The molecular profile of luminal B breast cancer

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