skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8838

Antipsychotics and risk of venous thromboembolism: A population-based case-control study

Original Research

(4034) Views  (764) Full article downloads

Authors: Anna K Jönsson, Erzsebet Horváth-Puhó, Staffan Hägg, Lars Pedersen, Henrik Toft Sørensen

Published Date March 2009 Volume 2009:1 Pages 19 - 26
DOI: http://dx.doi.org/10.2147/CLEP.S4969

Anna K Jönsson1, Erzsebet Horváth-Puhó2, Staffan Hägg3, Lars Pedersen4, Henrik Toft Sørensen4

1Nordic School of Public Health, Gothenburg, Sweden; 2Centre for Registry Research, Aarhus C, Denmark; 3Division of Clinical Pharmacology, Linköping University, Linköping, Sweden; 4Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark

Abstract: During the last decade, the risk of venous thromboembolism (VTE) has been reported in users of antipsychotic drugs. However, the reports have been inconclusive. This study aimed to determine the relative risk of VTE in antipsychotic drug users. Using data from medical databases in North Jutland and Aarhus Counties, Denmark, and the Danish Civil Registration System, we identified 5,999 cases with a first-time diagnosis of VTE and, based on risk set sampling, 59,990 sex- and age-matched population controls during 1997–2005. Users of antipsychotic drugs were identified from population-based prescription databases and categorized based on filled prescriptions prior to admission date for VTE or index date for controls as current (at least one prescription within 90 days), recent (at least one prescription within 91–180 days), former (at least one prescription within 181–365 days) or nonusers (no recorded prescription within 365 days). Compared with nonusers, current users of any antipsychotic drugs had an increased risk of VTE (adjusted relative risk [ARR]: 1.99, 95% confidence interval [CI]: 1.69–2.34). Former users of any antipsychotic drugs had a nonsignificant elevated risk of VTE compared with nonusers (ARR: 1.54, 95% CI: 0.99–2.40, p-value: 0.056). In conclusion, users of antipsychotic drugs have an increased risk of VTE, compared with nonusers, which might be due to the treatment itself, to lifestyle factors, to the underlying disease, or to residual confounding.

Keywords: antipsychotic agents, venous thromboembolism, adverse effects, case-control study








Readers of this article also read:

Breast cancer quality of life evaluation in Mexican Women at La Raza Hospital, Mexico City: A preliminary approach
Evidence-based decision-making within the context of globalization: A “Why–What–How” for leaders and managers of health care organizations
Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and acute inflammation in men with diabetes
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Utilization of preventive care services and their effect on cardiovascular outcomes in the United States
Erratum
Multiple causes of death models for human immunodeficiency virus/acquired immune deficiency syndrome and related mortality in South Africa in 2006 and 2007
Lower extremity venous thrombosis in patients younger than 50 years of age
Children and young adults with parents with cancer: a population-based study
Developmental trajectories of overweight and obesity of US youth through the life course of adolescence to young adulthood