A neuropsychiatric review of pediatric obsessive-compulsive disorder: etiology and efficacious treatments

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Authors: Adam B Lewin, Eric A Storch, Gary R Geffken, Wayne K Goodman, Tanya K Murphy

Published Date February 2006 Volume 2006:2(1) Pages 21 - 31

DOI: http://dx.doi.org/10.2147/NDT.S

Adam B Lewin, Eric A Storch, Gary R Geffken, Wayne K Goodman, Tanya K Murphy

Department of Psychiatry, University of Florida, Gainesville, FL, USA

Abstract: Pediatric obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition associated with broad impairments in functioning. This paper outlines current etiological theories of OCD, providing a review of neuroanatomical, neurochemical, neuroimmunological, and cognitive–behavioral explanations. Subsequently, first-line treatment modalities are discussed (serotonin reuptake inhibitors [SRIs] and cognitive–behavioral therapy [CBT] with exposure and response prevention [E/RP]) in the context of recent pharmacological, CBT, and combined trials.

Keywords: OCD, pediatric, etiology, treatment, serotonin reuptake inhibitors, cognitive behavioral therapy