Back to Browse Journals » Clinical Interventions in Aging » Volume 8

A critical appraisal of lubiprostone in the treatment of chronic constipation in the elderly

Authors Gras-Miralles B, Cremonini F

Published Date February 2013 Volume 2013:8 Pages 191—200


Received 24 October 2012, Accepted 17 December 2012, Published 15 February 2013

Beatriz Gras-Miralles,1 Filippo Cremonini1,2

1Gastroenterology Department, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 2Southern Nevada VA Healthcare System, Las Vegas, NV, USA

Abstract: Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization. Lubiprostone is an intestinal type-2 chloride channel activator that increases intestinal fluid secretion, small intestinal transit, and stool passage. Lubiprostone is currently approved by the US Food and Drug Administration for the treatment of chronic idiopathic constipation and of irritable bowel syndrome with predominant constipation. This review outlines current approaches and limitations in the treatment of chronic constipation in the elderly and discusses the results, limitations, and applicability of randomized, controlled trials of lubiprostone that have been conducted in the general and elderly population, with additional focus on the use of lubiprostone in constipation in Parkinson's disease and in opioid-induced constipation, two clinical entities that can be comorbid in elderly patients.
Keywords: irritable bowel syndrome, Parkinson's disease, opioid-induced constipation, chronic constipation

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Age-related decrease in physical activity and functional fitness among elderly men and women

Milanović Z, Pantelić S, Trajković N, Sporiš G, Kostić R, James N

Clinical Interventions in Aging 2013, 8:549-556

Published Date: 21 May 2013

Validation of a new mass screening tool for cognitive impairment: Cognitive Assessment for Dementia, iPad version

Onoda K, Hamano T, Nabika Y, Aoyama A, Takayoshi H, Nakagawa T, Ishihara M, Mitaki S, Yamaguchi T, Oguro H, Shiwaku K, Yamaguchi S

Clinical Interventions in Aging 2013, 8:353-360

Published Date: 26 March 2013

Swallowing disorders in nursing home residents: how can the problem be explained?

Nogueira D, Reis E

Clinical Interventions in Aging 2013, 8:221-227

Published Date: 19 February 2013

A review of minodronic acid hydrate for the treatment of osteoporosis

Tanishima S, Morio Y

Clinical Interventions in Aging 2013, 8:185-189

Published Date: 15 February 2013

Taste loss in hospitalized multimorbid elderly subjects

Toffanello ED, Inelmen EM, Imoscopi A, Perissinotto E, Coin A, Miotto F, Donini LM, Cucinotta D, Barbagallo M, Manzato E, Sergi G

Clinical Interventions in Aging 2013, 8:167-174

Published Date: 13 February 2013

Benefits and risks of weight-loss treatment for older, obese women

Rossen LM, Milsom VA, Middleton KR, Daniels MJ, Perri MG

Clinical Interventions in Aging 2013, 8:157-166

Published Date: 11 February 2013

Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study

Cotroneo AM, Castagna A, Putignano S, Lacava R, Fantò F, Monteleone F, Rocca F, Malara A, Gareri P

Clinical Interventions in Aging 2013, 8:131-137

Published Date: 5 February 2013

Anemia associated with chronic heart failure: current concepts

Shah R, Agarwal AK

Clinical Interventions in Aging 2013, 8:111-122

Published Date: 4 February 2013

A model for estimating body shape biological age based on clinical parameters associated with body composition

Bae CY, Kang YG, Suh YS, Han JH, Kim SS, Shim KW

Clinical Interventions in Aging 2013, 8:11-18

Published Date: 28 December 2012