skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8129

A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention

Review

(3919) Views  (1288) Full article downloads

Author: Ji-Guang Wang

Published Date July 2009 Volume 2009:5 Pages 593 - 605
DOI: http://dx.doi.org/10.2147/VHRM.S6203

Ji-Guang Wang

Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Abstract: Stroke is a leading cause of death and disability worldwide. The importance of lowering blood pressure for reducing the risk of stroke is well established. However, not all the benefits of antihypertensive treatments in stroke can be accounted for by reductions in BP and there may be differences between antihypertensive classes as to which provides optimal protection. Dihydropyridine calcium channel blockers, such as amlodipine, and angiotensin receptor blockers, such as valsartan, represent the two antihypertensive drug classes with the strongest supportive data for the prevention of stroke. Therefore, when combination therapy is required, a combination of these two antihypertensive classes represents a logical approach.

Keywords: stroke, angiotensin, calcium channel, cerebrovascular, hypertension, blood pressure
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University